Fmoc Amino Acid


Amino Acid Substituted Resins from AAPPTec

AAPPTec offers an extensive selection of amino acid substituted resins, each manufactured to fall within the 0.4 to 0.8 mmol/g substitution range. For more information about amino acid substituted resins and other AAPPTec resins for peptide synthesis, click here.

One problem often encountered in preparing amino acid substituted resins is incomplete reaction of all the reactive sites on the resin. Unless they are blocked, these unreacted sites can generate impurities that may be difficult to remove. This is especially important in preparing libraries. In combinatorial libraries, impurities can interfere in the library screening. Parallel libraries often are too large to allow practical purification of each library compound, therefore reducing the chances for impurities to form requires well-capped amino acid substituted resins. Inefficient attachment of the protected amino acid also lowers the useful substitution of the amino acid substituted resin, reducing the overall yield and efficiency of the solid phase synthesis. Any unreacted sites in AAPPTec amino acid substituted resins are capped to prevent the formation of truncated peptide impurities.

Partial racemization of the protected amino acids is another problem that can occur while preparing amino acid substituted resins. Numerous catalysts, activating agents, additives and reaction conditions have been tested to find the optimum conditions for preparing amino acid substituted resins. As may be expected, these conditions vary for the different resins. AAPPTec amino acid substituted resins are prepared by proven procedures that ensure good substitution and minimize racemization of the substrates. Each amino acid substituted resin is end-capped to block any remaining unreacted active resin sites that could interfere later in the synthesis.

AAPPTec Fmoc Amino Acid Substituted Resins (Wang)

For prices of AAPPTec Fmoc amino acid substituted resins (Wang), click here.

Catalog Number Resin
RWA101 Fmoc-Ala-Wang resin
RWA201 Fmoc-D-Ala-Wang resin
RWA102 Fmoc-1-Nal-Wang resin
RWA103 Fmoc-2-Nal-Wang resin
RWR105 Fmoc-Arg(Pbf)-Wang resin
RWD105 Fmoc-Asp(OtBu)-Wang resin
RWN105 Fmoc-Asn(Trt)-Wang resin
RWC105 Fmoc-Cys(Trt)-Wang resin
RWC110 Fmoc-Cys(Acm)-Wang resin
RWE105 Fmoc-Glu(OtBu)-Wang resin
RWQ105 Fmoc-Gln(Trt)-Wang resin
RWG101 Fmoc-Gly-Wang resin
RWH105 Fmoc-His(Trt)-Wang resin
RWH205 Fmoc-D-His(Trt)-Wang resin


Fmoc-Ile-Wang resin
RWL101 Fmoc-Leu-Wang resin
RWK105 Fmoc-Lys(Boc)-Wang resin
RWM101 Fmoc-Met-Wang resin
RWF101 Fmoc-Phe-Wang resin
RWF102 Fmoc-Phe(4-Cl)-Wang resin
RWF103 Fmoc-Phe(4-F)-Wang resin
RWF104 Fmoc-Phe(4-NO2)-Wang resin
RWP101 Fmoc-Pro-Wang resin
RWS105 Fmoc-Ser(tBu)-Wang resin
RWT105 Fmoc-Thr(tBu)-Wang resin
RWW101 Fmoc-Trp-Wang resin
RWW105 Fmoc-Trp(Boc)-Wang resin
RWY105 Fmoc-Tyr(tBu)-Wang resin
RWV101 Fmoc-Val-Wang resin
For prices of AAPPTec Fmoc amino acid substituted resins (Wang), click here.
AAPPTec Amino Acid Substituted Resins (2-Chlorotrityl)
For prices of AAPPTec amino acid substituted resins (2-Chlorotrityl), click here.
Catalog Number Resin
RTA101 H-Ala-2-Chlorotrityl resin
RTR105 H-Arg(Pbf)-2-Chlorotrityl resin
RTD105 H-Asp(OtBu)-2-Chlorotrityl resin
RTN101 H-Asn-2-Chlorotrityl resin
RTN105 H-Asn(Trt)-2-Chlorotrityl resin
RTC105 H-Cys(Trt)-2-Chlorotrityl resin
RTC106 H-Cys(Acm)-2-Chlorotrityl resin
RTE101 H-Glu-2-Chlorotrityl resin
RTE105 H-Glu(OtBu)-2-Chlorotrityl resin
RTQ101 H-Gln-2-Chlorotrityl resin
RTQ105 H-Gln(Trt)-2-Chlorotrityl resin
RTG101 H-Gly-2-Chlorotrityl resin
RTH105 H-His(Trt)-2-Chlorotrityl resin
RTI101 H-Ile-2-Chlorotrityl resin
RTL101 H-Leu-2-Chlorotrityl resin
RTK105 H-Lys(Boc)-2-Chlorotrityl resin
RTM101 H-Met-2-Chlorotrityl resin
RTF101 H-Phe-2-Chlorotrityl resin
RTP101 H-Pro-2-Chlorotrityl resin
RTS105 H-Ser(tBu)-2-Chlorotrityl resin
RTS106 H-Ser(Trt)-2-Chlorotrityl resin
RTT105 H-Thr(tBu)-2-Chlorotrityl resin
RTT106 H-Thr(Trt)-2-Chlorotrityl resin
RTW105 H-Trp(Boc)-2-Chlorotrityl resin
RTY105 H-Tyr(tBu)-2-Chlorotrityl resin
RTY106 H-Tyr(Trt)-2-Chlorotrityl resin
RTV101 H-Val-2-Chlorotrityl resin
For prices of AAPPTec amino acid substituted resins (2-Chlorotrityl), click here.


Related Links
Peptide Synthesizers
Merrifield Resin MBHA Resin Fmoc Amino Acids Peptides